HELPING THE OTHERS REALIZE THE ADVANTAGES OF LIGAZ FOOTBALL

DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by means of a few nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal constructions of DNA ligases bound to nucleoti